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  3. Investigating the status of periodontal indicators in HTLV-I infected people and comparing it with healthy people

Investigating the status of periodontal indicators in HTLV-I infected people and comparing it with healthy people

Number of pages: 82 File Format: word File Code: 31917
Year: 2014 University Degree: Master's degree Category: Medical Sciences
Tags/Keywords: attachment loss - Gum analysis - HTLV-1 - oral hygiene - Periodontal indicators - Periodontal pocket - periodontium
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  • Summary of Investigating the status of periodontal indicators in HTLV-I infected people and comparing it with healthy people

    Dissertation for receiving a doctorate degree in dentistry

    Abstract:

    Introduction: HTLV_1 virus is one of the human retroviruses, which in some patients is the cause of leukemia of T lymphocyte cells and myelopathy related to HTLV-1 and some other inflammatory diseases. Considering the endemicity of Khorasan to HTLV-1 virus and the existence of few studies on the relationship between this virus and periodontal diseases, the purpose of this study is to investigate the status of periodontal indicators in people infected with HTLV-I and compare it with healthy people. Materials and methods: In this case-control study, 40 patients with an average age of 42.3 years who were infected with HTLV-1 virus were studied. were placed The patients were selected from those who referred to Qaim Hospital in Mashhad. The periodontal condition of these people was evaluated with the help of 6 indices of bleeding during probing, plaque index, gingival index, probe depth, attachment loss and the amount of gingival erosion. The control group consisted of 40 people who were referred to Qaim Hospital (AJ) who had a negative HTLV-1 test and were matched with the patient group in terms of age and sex. The results were analyzed using independent t and Wilcoxon tests.

    Findings: There is no significant relationship between pocket depth, attachment loss and the amount of gingival analysis used in the study and the presence or absence of HTLV-1 disease. Of course, in the case of all three mentioned indicators, their average was higher in patients with HTLV-1 virus than healthy people. On the other hand, plaque index, gingival index and bleeding during probing were significantly higher in the group of patients with HTLV-1 than in healthy individuals.

    Conclusion: Patients with HTLV-1 have more plaque and inflammation in the periodontal tissue than normal people. Strict adherence to oral hygiene and timely scaling will significantly reduce the problems of these patients.

    Key words: periodontal indicators, HTLV-1, periodontal pocket, attachment loss

    Chapter one:

     

     

    Review of texts and articles

    Introduction:

     

    Interaction of systemic diseases and disease Periodontal has been noticed in recent years. Systemic diseases such as diabetes, hyperlipidemia, etc. can affect the periodontium. On the other hand, several studies have proven the effect of periodontal infections on heart diseases (atherosclerosis), premature birth, COPD, etc. (1-3) One of the problems of Khorasan province is the spread of a virus from the family of retroviruses called HTLV-I (Human lymphotropic virus type 1). This virus can cause ATL (Adult T cell leukemia) and also cause neurological disorders, which is called HAM (HTLV-I associated myelopathy). The existence of endemic centers is one of the epidemiological characteristics of this virus, which is the southwest of Japan, the Caribbean, central and southern Africa, Italy, and Israel. In Iran, Khorasan, especially the cities of Neishabur and Mashhad, have been reported as an endemic center with a serum prevalence of 2.3%. (4, 5) Due to the lack of sufficient studies on the periodontal status of these patients, in this research, we examine the status of periodontal indices in these patients. These findings may help us to understand how periodontal disease is caused or how it is made worse by other factors, so that perhaps by controlling this virus as much as possible, other diseases related to it can be prevented and its treatment can be more knowledgeable and capable. rtl;"> 

    Human T-Cell lymphotropic virus type I (HTLV-I) is the first human retrovirus that was discovered in 1980 in America in Dr. Callo's laboratory by Poise. On that date, Dr.

     

    Overview:

    Human T-Cell lymphotropic virus type I (HTLV-I) is the first human retrovirus that was discovered in 1980 in the United States in the laboratory of Dr. Callo by Poise, Dr. Poise and Their colleagues on the patient who had cutaneous lymphoma.  They were studying. The skin lesion of this patient was called T-cell lymphoma or mycosis fungoides. On that date, interleukin 2 had just been discovered in Dr. Gallo's laboratory, and his colleagues used this cytokine to multiply the cells of the above patient. Dr. Poise used the RT method to further multiply the cells and then evaluated the multiplied components under the electron microscope and noticed the presence of virus components inside the T cells of the patient. Finally, after Gallo's research and further investigations, Poise and his colleagues published the first article in this field in 1980 in the Journal of the American Academy of Sciences, and then Dr. Poner published a more comprehensive article in 1981 in Nature magazine, and he was given the honor of discovering this retrovirus in Gallo's laboratory. Adult T-cell malignancy is called adult T-cell lymphoma (ATL). At the same time, Professor Takatsuki and his colleagues succeeded in isolating this virus from a patient with leukemia, which was different from other blood malignancies, and this type of blood cancer, which was related to the HTLV-I virus, was also called ATL. Japanese scientists succeeded in collaborating with Dr. Gallo. HTLV-I antibody was evaluated and in terms of serological diagnosis, this action was very significant. According to the findings of American and Japanese scientists, finally, in March 1981, the first scientific meeting about this virus was held on Miwa Island in Japan, outside of the city of Kyoteri, Japan. At the same time, similar cases of ATL and clinical symptoms of some leukemias, which were completely different from other leukemias, were also seen in Mashhad. Dr. Farid Hosseini and Dr. Tabibi from Shiraz studied these patients and reported cases of new ALT leukemia. However, since the serology test had not yet been launched in Mashhad, Dr. Farid submitted the sample to the American NIH at the invitation of Professor Waldman. After a complete study, he was diagnosed with HTLV-I-related leukemia of the ATL type. rtl;">At the Japanese scientific meeting, one of the researchers named Hinoma presented an article about the new retrovirus that he has been working on, in which the image of the retrovirus components was displayed. Hinoma called this isolated virus ATLV or Adult T-cell leukemia virus, and at the same time, another Japanese scientist named Miyoshi isolated the virus components from a patient with leukemia in 1981, and in 1983, in America, Popovic succeeded in isolating retrovirus components from patients with a type of leukemia. After scientific research, the Japanese and Dr. Gallo's group came to the conclusion that ATLV and HTLV are the same virus.

    The second historic meeting of retroviruses was held in London in 1983 under the chairmanship of the famous English hematologist John Dicey, and it was named HTLV-I according to the phylogeny and mode of transmission and pathogenesis of this virus.

     

    Abstract:

     

    Introduction:

    HTLVI virus is one of human's retroviruses which is the cause of T Lymphocytes Leukemia and spastic parpareseis or HTLVI associated myelopathy and some other inflammatory diseases, in some patients. Regarding that HTLVI is an endemic virus in Khorasan and the lack of studies and researches about association of this virus with periodontal disease, the aim of this study periodontal indexes in HTLV-I-infected individuals compared with healthy people are. which confirms that HTLV-1 infection was studied.

  • Contents & References of Investigating the status of periodontal indicators in HTLV-I infected people and comparing it with healthy people

    List:

    Persian abstract..1

    Chapter one: review of texts and articles.2

    Chapter two: methodology and materials.30

    Chapter three: findings..38

    Chapter four: discussion..51

    Chapter five: conclusions and suggestions.57

    Resources..60

    English abstract..65

    Source:

    Reference:

     

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    Zadeh Modares Shahrazad*, Amouiyan Babak, Bayat Mohd Saeed, Mohammadi Mansoura, Sheikhul Islami Fereshte, Sheikhul Islami Leila. Comparison of gum health in mothers with premature birth and mothers with full-term birth in Mahdieh Hospital, Tehran, in 2011-2018. Dental Journal (Tehran University of Medical Sciences) spring 2016; 20(1 (series 50)):53-58.

    Faryal Taleghani, Sadeghian Saeed, Sadeghi Rukhsare, Darafshan Abdolreza. Investigating the relationship between periodontal diseases and ischemic heart disease. Dental Journal of the Islamic Society of Dentists Winter 1386 : 19 (4), 76-83.

    Farid Hosseini Reza, Safai Bijan. Investigation of virology and seroepidemiology of HTLV-1 in Khorasan. Journal of the Faculty of Medicine, Mashhad University of Medical Sciences, 1371; 35(Supplement No. 39):58-61.

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Investigating the status of periodontal indicators in HTLV-I infected people and comparing it with healthy people
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