Determining the relationship between colorectal polyps and BMI in people who underwent colonoscopy at Hazrat Masoumeh (pbuh) and Shahid Beheshti hospitals in Qom from November 2018 to September 2019.

- Introduction

Colorectal cancer is the second cause of death due to cancer after lung cancer in the United States.  In 2007, there were 52,180 new cases of colon cancer and death due to colorectal cancer. Colorectal cancer is the most common gastrointestinal cancer in the United States; The incidence of colorectal cancer in this country has remained unchanged for the past 30 years (1). In Iran, despite the lack of accurate statistics, we are facing an increase in the incidence of colorectal cancer due to the increased use of the western diet.

Most colorectal cancers, regardless of etiology, originate from adenomatous polyps. It is divided into hyperplastic polyp and adenomatous polyp. Only adenomatous polyp is a premalignant lesion.

Recently, obesity has been estimated to be the cause of 14% of cancer deaths in men and 20% of cancer deaths in women in the United States. Obesity is also associated with insulin resistance and type 2 diabetes, cardiovascular diseases, lung diseases such as obstructive sleep apnea, gallstones, and joint diseases (1).

About obesity BMI >30 and overweight BMI >25 with colorectal polyps; a precursor to cancer; there is a relationship, there are many articles (2,3,9,11). In some studies, this relationship was only in men (8.5.4) and no significant relationship was found in women; But in other studies, this prevalence has also been found in women (1.7).

Since there has been no study in this regard in Iran and Qom province, we decided to find a more accurate relationship between colon polyps and BMI. In this study, the relationship between polyp and age and gender and the relationship between BMI and the location of the polyp were also examined.

Of course, there are other indicators for obesity besides BMI, such as waist size and waist-to-hip ratio; But in this study, we used BMI as a measure of obesity and overweight.

Considering the increase in the incidence of all types of cancer in society, especially colon cancer, as well as the increase in the incidence of obesity following the use of a western diet and inactivity, if there is a relationship between polyps as a precursor to cancer and BMI; It is possible to prevent the creation of polyps and then cancer by recommending to maintain BMI in the normal range. 2- Research objectives style="direction: rtl;">

- Determining the relationship between colorectal polyps and BMI in people who underwent colonoscopy at Hazrat Masoumeh (pbuh) and Shahid Beheshti hospitals in Qom from November 1987 to Shahrivar 1990.

2-Research objectives

A - The main objective of the project:

- Determining the relationship between colorectal polyps and BMI in people who underwent colonoscopy at Hazrat Masoumeh (pbuh) and Shahid Beheshti hospitals in Qom from November 1987 to Shahrivar 1990. style="direction: rtl;">- Determining the relationship between colorectal polyps and BMI in colonoscopied women

- Determining the relationship between colorectal polyps and BMI in colonoscopied men

- Determining the relationship between colorectal polyps and age in colonoscopy subjects

- Determining the relationship between colorectal polyps and gender in colonoscopy subjects

- Determining the relationship between the location of colorectal polyps and BMI in colonoscopy subjects

3-Research questions

-Is there a relationship between colorectal polyps and BMI in colonoscopy subjects at Hazrat Masoumeh (pbuh) and Shahid Beheshti Hospital, Qom Is there a relationship between November 87 and September 90?

- Is there a relationship between colorectal polyps and BMI in women who underwent colonoscopy?

- Is there a relationship between colorectal polyps and BMI in men who underwent colonoscopy?

- Is there a relationship between colorectal polyps and age in colonoscopy subjects?

- Is there a relationship between colorectal polyps and gender in colonoscopy subjects?

- Is there a relationship between the location of colorectal polyps and BMI in colonoscopy subjects

4-Limitations of the research

Unfortunately, because many people in our society do not follow the routine screening for colon cancer, it was not possible to investigate the general population; Although this causes a selection bias in the selection of the sample, we had to face this bias.

A number of checklists were excluded from the study because the information was not entered completely. The size and number of polyps were not included in all checklists, so we could not check these variables.

We could only use BMI as a measure of obesity, and due to the lack of information, waist size and waist-to-hip ratio were not used, although they might be valuable in our review.

If the data were collected and stored in a computer; They were easier to collect and study and analyze. 5-Words and Terms Colonoscopy is seen and based on histology, it is divided into different types: hamartoma, hyperplastic polyp, and adenomatous polyp, only adenomatous polyp is a premalignant lesion. rtl;">5/18>          = underweight

9/18-24    = normal

9/25-29     = overweight

>30            = fat

Abstract

Background: Cancer of the large bowel is second only to lung cancer as a cause of cancer death in the United States. Most colorectal cancers, regardless of etiology, arise from adenomatous polyps. There are many articles about obesity and polyp but their association is not approved in all of them. we decide to evaluate this association.

Method and Matherial: We used BMI to evaluate the degree of obesity. 1387 to Shahrivar 1390. data were analyzed by SPSS ver 19.

Result : 77(11.9%) of 642 women and 122(17.2%) of 708 men had polyp. While 114 of 199 persons who had polyp were overweight but in our study there were not meaningful relation between the polyp and BMI (P=0.812). Multiple logistic regression analysis was used to determine independent predictors for polyp. Sexuality was an independent risk factor (p=0.006). Age was relatively independent association with polyp (p=0.07) but BMI was not an independent risk factor. Between polyp and BMI in women (p=0.74) and men (p=0.19) were not meaningful association.

conclusion: polyp prevalence in men were 1.5 times more than women. While mean of BMI in who had polyp were 0.3 more than who had not but in our study this association was not statistically significant.